The mechanism of response is consistent with preclinical studies, including substantial reduction of plasma 2HG, as well as evidence of cellular differentiation and normalization of cell counts in the bone marrow and blood. Extensive publications led by Agios scientists validate our belief that these mutations are initiating and driving events in many cancers. We do not currently have arrangements in place for redundant supply for bulk drug substance. A germline mutation in IDH2, identical to that of cancer patients, has recently been discovered in patients with an ultra-rare, extremely debilitating, and uniformly fatal, genetic neurometabolic disorder called Type II D-2 hydroxyglutaric aciduria. Description of capital stock. If third parties prepare and file patent applications in the United States that also claim technology or therapeutics to which we have rights, we may have to participate in interference proceedings in the USPTO to determine priority of invention, which could result in substantial costs to us, even if the eventual outcome is favorable to us. This differentiation effect is distinct from that seen with traditional chemotherapeutics commonly used to treat AML.

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We are also eligible to receive an additional extension payment, payments upon the successful achievement of specified milestones, reimbursements for certain development expenses and royalties on certain product sales. In Septemberwe initiated a phase 1 study for AG in patients with advanced hematologic malignancies with an mutation.

We have granted the underwriters the right to purchase up to an additionalshares of our common stock. Research and development expenses. You will not receive a coupon payment in respect of any observation date where the Closing Price of the underlying ho is below the Coupon Barrier.

Following the discovery phase until termination or expiration of the agreement, either in its entirety or with respect to the relevant program, we may not directly or indirectly develop, manufacture or commercialize, outside of the collaboration, any therapeutic modality with specified activity against any collaboration target that is within a licensed program.

In addition, because of the extensive time required for clinical development and regulatory review of a product candidate we may develop, it is possible that, before any of our product candidates can be commercialized, any related patent may expire or remain in force for only a short period following commercialization, thereby reducing any advantage of any such patent.


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We also cannot predict the breadth of claims that may be allowed or enforced in our patents. Agios estimates that between 1, diagnosed patients are alive in the U. There are a variety of available drug therapies marketed for cancer. Our historical results are not necessarily indicative of future results.

As in our efforts to develop therapeutics for cancer, we create a crystal structure of the enzyme to begin the process of drug design. The FDA also may respond with a not approvable determination based on deficiencies in the application and require additional clinical esg-shv.wca that are often expensive and time-consuming and can substantially delay approval. Table of Contents means that disease had progressed after or was refractory to between one and four prior therapies, were treated with either 30 mg or 50 mg of AG orally twice daily.

We will need substantial additional funding. In DecemberCelgene notified us of its intent to extend the discovery phase of the strategic collaboration by one year, extending the initial period of esg-shv.scx from four years to five years.

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Metabolites make ideal ph because they are readily measured in the tissues and blood. In recent decades, hundreds of new IEMs have been discovered and the categories have proliferated. We have never declared or paid cash dividends on our capital stock. Cautionary note regarding forward-looking statements. This includes the shares that we are issuing and selling in this offering, which shares may be resold in the public market immediately without restriction, unless purchased by our affiliates.

While these drugs, e. In Marchwe initiated two phase 1 studies for our lead development candidate in the IDH1 program, AG, one in patients with either advanced hematologic malignancies and the second in patients with advanced solid tumors, both trials only enrolling patients with an IDH1 mutation. You may transfer the Software only if the recipient agrees to be fully bound by these terms and if you retain no copies of the Software.


Upon completion of this offering, our executive officers, directors and a small number of our stockholders will continue to own more than a majority of our outstanding common stock. The Agios team has already studied more than 50 metabolic enzymes as possible important cancer targets.

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Of the seven evaluable patients, six patients had investigator-assessed objective responses, including three patients who achieved complete remission CRtwo patients who achieved complete remission with incomplete platelet recovery CRp and one patient with a partial response PR. All statements, other than statements of historical facts, contained in this prospectus, including statements regarding our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans and objectives of management are forward-looking statements.

Industry and other data. Within the 22 patients enrolled as of March 20,possible drug-related severe adverse events were reported in two patients. Our lead development candidate, AG, is a potent, orally available small molecule activator of the PKR enzyme, an isoform of PK that, when mutated, leads to PK deficiency. In the early stages of biomarker development, we create a responder hypothesis, comparing the molecular genetics and metabolite patterns between cancers that respond to treatment to those that do not respond to enzyme inhibition.

Incidence of IDH mutations. In Marchwe initiated two phase 1 studies for AG, one in patients with advanced hematologic malignancies and the second in patients with advanced solid tumors, both trials only enrolling patients with an IDH1 mutation. They can be manufactured in reliable and reproducible synthetic processes from readily available starting materials.